大鼠衰老过程中与脑微血管酶相关的通透性功能

Permeability function related to cerebral microvessel enzymes during ageing in rats.

作者信息

Agrawal A, Shukla R, Tripathi L M, Pandey V C, Srimal R C

机构信息

Division of Biochemistry, Central Drug Research Institute, Lucknow, India.

出版信息

Int J Dev Neurosci. 1996 Apr;14(2):87-91. doi: 10.1016/0736-5748(95)00086-0.

DOI:10.1016/0736-5748(95)00086-0

PMID:8735783

Abstract

Cerebral microvessels from rats were prepared and characterized by their enrichment of specific markers, namely alkaline phosphatase (AP) and tau-glutamyl transpeptidase (tau-GT). Further, it was observed that AP and tau-GT registered marked increase in aged rats. On the contrary, lactate dehydrogenase (LDH) activity decreased with the increasing age. Monoamine oxidase A activity in the microvessels decreased with age whereas MAO-B moved in the reverse direction. No noticeable change was seen in acetyl-cholinesterase activity with increasing age of rats.

摘要

制备大鼠脑微血管，并通过其对特定标志物（即碱性磷酸酶（AP）和tau-谷氨酰转肽酶（tau-GT））的富集进行表征。此外，观察到老年大鼠的AP和tau-GT显著增加。相反，乳酸脱氢酶（LDH）活性随年龄增长而降低。微血管中的单胺氧化酶A活性随年龄下降，而单胺氧化酶B则呈相反变化。随着大鼠年龄增长，乙酰胆碱酯酶活性未见明显变化。