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无聊、抑郁与老年痴呆症的生理学

The physiology of boredom, depression and senile dementia.

作者信息

Saunders M N

机构信息

Green Gables, South Humberside, UK.

出版信息

Med Hypotheses. 1996 May;46(5):463-6. doi: 10.1016/s0306-9877(96)90026-2.

Abstract

Mental stimulation ensures the flow of blood, oxygen and nutrients to the brain. The stimulation can be either generated internally from thought and rumination or externally from our environment via the senses. Without this stimulation, neuron shrinkage and atrophy eventually may lead to depression and senile dementia. This paper explains why mental stimulation may be prevented from realizing its beneficial effects of increasing the blood flow to the brain. The hypothesis is based on feedback biological mechanisms that prevent overload of the neural circuitry due to excessive mental stimulation. However, if overstimulation is maintained over a long period and, with it, the overload protection process, it may eventually lead to permanent depletion of neuron connections and also neural communications.

摘要

精神刺激可确保血液、氧气和营养物质流向大脑。这种刺激既可以源于内心的思考和冥想,也可以通过感官从外部环境获取。没有这种刺激,神经元萎缩最终可能导致抑郁和老年痴呆。本文解释了为何精神刺激可能无法实现其增加脑部血流量的有益效果。该假设基于反馈生物机制,这种机制可防止因过度精神刺激导致神经回路过载。然而,如果长期持续过度刺激以及随之而来的过载保护过程,最终可能导致神经元连接和神经通讯的永久性损耗。

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