Doenecke D, Alonso A
Institut für Biochemie und Molekulare Zellbiologie, Georg-August-Universität Göttingen, Germany.
Int J Dev Biol. 1996 Feb;40(1):395-401.
The H1 class of histones comprises several main-type, S-phase dependent isoforms and, in addition, a sperm-specific H1t and a peculiar subtype, H1 zero, which is confined to highly differentiated cells. In contrast to main type histone genes, the H1 zero gene expression does not strictly depend on DNA replication. Also in contrast to the other H1 subtype genes, the mammalian H1 zero gene is not included in a histone gene cluster and its mRNA differs in structure, size and mode of processing from other histone mRNAs. The regulation of expression of the H1 zero gene varies from main type H1 genes in several respects. This is manifested in the promoter structure which contains sequence elements that are also found in main type H1 promoters, but also shows regulatory motifs which appear to be involved in a developmental regulation of the H1 zero gene, such as a retinoic acid receptor binding site, which has been described in the mammalian H1 zero gene promoter.
组蛋白H1家族包含几种主要类型、依赖于S期的亚型，此外，还有精子特异性的H1t和一种特殊亚型H1零，后者局限于高度分化的细胞中。与主要类型的组蛋白基因不同，H1零基因的表达并不严格依赖于DNA复制。同样与其他H1亚型基因不同，哺乳动物的H1零基因不包含在组蛋白基因簇中，其mRNA在结构、大小和加工方式上与其他组蛋白mRNA不同。H1零基因表达的调控在几个方面与主要类型的H1基因不同。这表现在启动子结构上，它包含在主要类型H1启动子中也能找到的序列元件，但也显示出似乎参与H1零基因发育调控的调控基序，如在哺乳动物H1零基因启动子中已被描述的视黄酸受体结合位点。
