Arieli R
Israeli Naval Hyperbaric Institute, Haifa, Israel.
J Basic Clin Physiol Pharmacol. 1994 Jan-Mar;5(1):67-87.
The quantification of O2 toxicity as a function of exposure time (t) and PO2 has been based mainly on the empirical rectangular hyperbola. The non-linear response of the O2-damaged physiological variable (DMG) as a function of time at constant PO2 can be related to the dependence of dDMG/dt on the DMG. The kinetics of the O2-derived chemical species suggests a power relationship between the DMG and PO2 rather than a linear relationship. The combination of time and PO2 considerations suggests two models: 1) DMG = a(ebt - 1) PO2c and 2) DMG = a.tbPO2c, where a, b and c are constant. Non-linear regression of the different parameters of O2 toxicity showed a preference for model 2, with b = 2. Possible mechanisms underlying the kinetics of O2 toxicity and the use of the equation for its prediction are discussed.
作为暴露时间（t）和氧分压（PO2）函数的氧毒性定量主要基于经验性的矩形双曲线。在恒定PO2下，氧损伤生理变量（DMG）作为时间函数的非线性响应可能与dDMG/dt对DMG的依赖性有关。氧衍生化学物质的动力学表明DMG与PO2之间是幂函数关系而非线性关系。综合考虑时间和PO2因素，提出了两种模型：1）DMG = a(ebt - 1) PO2c和2）DMG = a.tbPO2c，其中a、b和c为常数。对氧毒性不同参数进行非线性回归分析表明，模型2更合适，b = 2。本文还讨论了氧毒性动力学的潜在机制及其预测方程的应用。
