Oliveira M C, Moraes J T, Barros H M, Barbosa-Coutinho L M
Disciplinas de Endocrinologia, Fundação Faculdade Federal de Ciências Médicas, Porto Alegre, RS, Brasil.
Braz J Med Biol Res. 1996 Apr;29(4):521-5.
The use of estrogen and dopamine receptor antagonists is associated with elevated prolactin levels and, in rats, chronic estrogen treatment is also associated with lactotroph proliferation. In this study, haloperidol, fluphenazine, sulpiride and metoclopramide, alone or combined with estradiol, were administered to Wistar rats. Pituitary weight, serum prolactin levels and percent of immunoreactive prolactin cells in the anterior pituitary glands were determined at the end of 60 days of treatment. The pituitary weight of rats treated with estrogen alone or in combination with other drugs was significantly higher than the control group. The serum prolactin level was higher than the upper confidence limit in all but three of the 90 treated rats. While in the control group the percent of immunoreactive prolactin cells was 20%, administration of the neuroleptic drugs and metoclopramide increased this percent to approximately 30%, and estrogen alone or in combination with one of the neuroleptic drugs increased it to approximately 40%. The results presented here demonstrate the relationship between prolactin secretion and prolactin cell number when different neuroleptics and related drugs are used.
雌激素和多巴胺受体拮抗剂的使用与催乳素水平升高有关，并且在大鼠中，长期雌激素治疗也与催乳素细胞增殖有关。在本研究中，将氟哌啶醇、氟奋乃静、舒必利和甲氧氯普胺单独或与雌二醇联合给予Wistar大鼠。在治疗60天结束时，测定垂体重量、血清催乳素水平以及垂体前叶中免疫反应性催乳素细胞的百分比。单独使用雌激素或与其他药物联合使用的大鼠的垂体重量显著高于对照组。在90只接受治疗的大鼠中，除3只外，所有大鼠的血清催乳素水平均高于置信上限。对照组中免疫反应性催乳素细胞的百分比为20%，给予抗精神病药物和甲氧氯普胺后，这一百分比增加到约30%，单独使用雌激素或与其中一种抗精神病药物联合使用时，该百分比增加到约40%。此处呈现的结果表明了使用不同抗精神病药物及相关药物时催乳素分泌与催乳素细胞数量之间的关系。
