Kaposi's sarcoma with primary bone lesions in an HIV-seronegative man.

Classic Kaposi's sarcoma, with primary bone lesions, is described in an HIV-seronegative man. The bone involvement, painful lytic lesions in the right leg and both feet, was shown by magnetic resonance and histology not to be contiguous with the skin lesions. Chemotherapy with vinblastine and doxorubicin, significantly reduced the skin and bone lesions, and pain also improved.