Feuerstein T J, Hüring H, van Velthoven V, Lücking C H, Landwehrmeyer G B
Sektion Klinische Neuropharmakologie, Neurologische Universitätsklinik, Neurozentrum, Freiburg, Germany.
Neurosci Lett. 1996 May 17;209(3):210-4. doi: 10.1016/0304-3940(96)12637-9.
Both human and rabbit brain contain the 5-hydroxytryptamine (5-HT)1D subtype of 5-HT1 receptors. We studied the effects of 5-HT1D receptor stimulation on neocortical [3H] gamma-aminobutyric acid (GABA) release from GABAergic neurons in these species. The 5-HT1D receptor agonist sumatriptan depressed [3H]GABA release in human neocortex and the 5-HT1 receptor antagonist metitepin prevented this depression with potencies suggesting mediation by 5-HT1D-like receptors. In rabbit neocortex, however, 5-HT1D agonists did not affect the release of [3H]GABA. Since 5-HT and GABA seem to function antagonistically in anxiety disorders their neocortical interaction may be (patho)physiologically relevant.
人类和兔脑均含有5-羟色胺（5-HT）1受体的5-HT1D亚型。我们研究了5-HT1D受体激动对这些物种新皮质中GABA能神经元释放[3H]γ-氨基丁酸（GABA）的影响。5-HT1D受体激动剂舒马曲坦抑制人类新皮质中[3H]GABA的释放，5-HT1受体拮抗剂美替平可防止这种抑制，其效力提示由5-HT1D样受体介导。然而，在兔新皮质中，5-HT1D激动剂并不影响[3H]GABA的释放。由于5-HT和GABA在焦虑症中似乎发挥拮抗作用，它们在新皮质中的相互作用可能具有（病理）生理相关性。
