Pazzaglia U E
Facolta di Medicina e Chirurgia dell'Università di Brescia, Italy.
Biomaterials. 1996 May;17(10):1009-14. doi: 10.1016/0142-9612(96)84676-x.
The reaction of bone to titanium implants of different shapes inserted in the rabbit tibia was investigated with histological and perfusion techniques to determine the pattern of vessel distribution. The experimental implants included full cylindrical rods, hollow rods with holes on the surface and wire mesh rods. In the implanted bones the rods were found to fill a large area of the medullary canal; however, owing to the discrepancy between the shape of the diaphysis and the implant, the endosteal contact was never complete. In an early phase, reactive bone filled the gap between the endosteal and the implant surface; in hollow and wire mesh rods bone had grown inside through the lateral holes or loops of the mesh. Revascularization took place together with remodelling of the endosteal, primary bone to mature lamellar. In full implants a reticle of newly formed vessels developed around the rods; in hollow and wire mesh implants vessels had grown inside the implant itself and the endosteal surface had a more regular profile than in full rods. Wire mesh plugs prevented formation of a peripheral medullary space and showed no encapsulation; wires in contact with or in proximity to the endosteal surface were incorporated by lamellar systems with strong connections with the original cortical bone.
采用组织学和灌注技术，研究了兔胫骨中植入不同形状钛植入物后骨的反应，以确定血管分布模式。实验植入物包括实心圆柱形棒、表面有孔的空心棒和金属丝网棒。在植入骨中，发现棒占据了髓腔的大片区域；然而，由于骨干形状与植入物之间的差异，骨内膜接触从未完全实现。在早期阶段，反应性骨填充了骨内膜与植入物表面之间的间隙；在空心棒和金属丝网棒中，骨通过网孔或网圈从侧面生长到内部。血管再生与骨内膜的重塑同时发生，即原发性骨转变为成熟的板层骨。在实心植入物中，围绕棒形成了新形成血管的网状结构；在空心和金属丝网植入物中，血管在植入物内部生长，并且骨内膜表面比实心棒中的轮廓更规则。金属丝网塞阻止了外周髓腔空间的形成，并且没有出现包囊；与骨内膜表面接触或接近的金属丝被板层系统整合，并与原始皮质骨有牢固连接。
