Dawes N J, Cox V M, Park K S, Nga H, Goldspink D F
Muscle Research Unit, Research School of Medicine, University of Leeds, UK.
Exp Physiol. 1996 May;81(3):329-39. doi: 10.1113/expphysiol.1996.sp003937.
The mRNA levels of the proto-oncogenes c-fos and c-jun were measured in the rabbit latissimus dorsi (LD) muscle in response to the application of various stretch regimes in vivo. It was shown that it was necessary for the stretch to be applied continuously over 1 h in order to achieve full induction of c-fos and c-jun mRNA at 1 h. In addition, a correlation was demonstrated between the degree of stretch imposed on the LD and the induced levels of c-fos and c-jun mRNA. Moreover, a second induction of these genes occurred when the LD was subjected to a second stretch stimulus. The magnitude and time course of the second response depended on the precise timing of the second stimulus in relation to the initial induction.
在体内对兔背阔肌（LD）施加不同的拉伸方案后，测量原癌基因c-fos和c-jun的mRNA水平。结果表明，为了在1小时时实现c-fos和c-jun mRNA的完全诱导，有必要连续施加拉伸1小时以上。此外，还证明了施加在LD上的拉伸程度与诱导的c-fos和c-jun mRNA水平之间存在相关性。此外，当LD受到第二次拉伸刺激时，这些基因会再次诱导。第二次反应的幅度和时间进程取决于第二次刺激相对于初始诱导的精确时间。
