Edwards A V, Tobin G, Ekström J, Bloom S R
Physiological Laboratory, University of Cambridge, UK.
Exp Physiol. 1996 May;81(3):349-59. doi: 10.1113/expphysiol.1996.sp003939.
The role of nitric oxide (NO) in mediating various submandibular responses to stimulation of the parasympathetic innervation has been investigated in anaesthetized cats, in which N omega-nitro-L-arginine methyl ester (L-NAME; 30 mg kg-1 I.A.) was used to block the synthesis of NO. L-NAME significantly reduced the vasodilator response and the flow of saliva, together with the output of salivary protein that occurred during stimulation of the chorda lingual nerve (20 Hz for 1 s at 10 s intervals), without significantly reducing the output of vasoactive intestinal peptide (VIP) from the gland. The results show that NO is implicated not only in the release of VIP, as established previously, but also in mediating its actions following release in the submandibular gland of the cat.
在麻醉猫身上研究了一氧化氮（NO）在介导下颌下腺对副交感神经支配刺激的各种反应中的作用，其中使用Nω-硝基-L-精氨酸甲酯（L-NAME；30 mg kg-1腹腔注射）来阻断NO的合成。L-NAME显著降低了血管舒张反应和唾液流量，以及在刺激舌神经（20 Hz，持续1 s，间隔10 s）期间发生的唾液蛋白分泌，而没有显著降低腺体中血管活性肠肽（VIP）的分泌。结果表明，NO不仅如先前确定的那样参与VIP的释放，还在猫下颌下腺释放后介导其作用。
