Sendo T, Adachi K, Otsubo K, Aoyama T, Oishi R
Department of Hospital Pharmacy, Faculty of Medicine, Kyushu University, Fukuoka Japan.
J Clin Pharm Ther. 1996 Feb;21(1):9-13. doi: 10.1046/j.1365-2710.1996.88875888.x.
Filter occlusion during intravenous infusion of injectable menatetrenone in an electrolyte fluid was examined. The menatetrenone concentration and its emulsion droplet size were not changed by in-line filtration. However, particle counts in the admixed solution and examination of scanning electron micrographs of the surface of the filter membrane indicated that particle formation occurred immediately after the admixture of menatetrenone injection with Hicaliq No. 2, but not with 5% glucose injection. This may be due to the interaction of excess lecithin in the emulsion with the electrolyte. Filter occlusion also occurred with the admixture of menatetrenone-free emulsion and Hicaliq No. 2, but not with 5% glucose injection. These findings indicate that injectable menatetrenone should not be admixed with electrolyte fluids.
对静脉输注电解质溶液中注射用甲萘醌时的过滤器堵塞情况进行了检查。通过在线过滤，甲萘醌浓度及其乳液滴大小未发生变化。然而，混合溶液中的颗粒计数以及对滤膜表面扫描电子显微镜图像的检查表明，甲萘醌注射液与希卡利克2号混合后立即出现颗粒形成，但与5%葡萄糖注射液混合时未出现。这可能是由于乳液中过量的卵磷脂与电解质相互作用所致。无甲萘醌乳液与希卡利克2号混合时也会发生过滤器堵塞，但与5%葡萄糖注射液混合时不会。这些发现表明，注射用甲萘醌不应与电解质溶液混合。
