De Leo V, Lanzetta D, D'Antona D, De Palma P
Department of Obstetrics and Gynecology, University of Siena, Italy.
Gynecol Endocrinol. 1996 Feb;10(1):49-53. doi: 10.3109/09513599609041270.
The effects of 6 months of hormone replacement therapy by transdermal estradiol patches (0.05 mg/day for 21 days) and oral progestogens (10 mg/day for 10 days) on hypothalamic-pituitary-ovarian function was evaluated in 32 perimenopausal women, aged 42-47 years, with irregular anovulatory cycles and menopausal symptoms. Hormone levels evaluated on the 8th and 24th day of the cycle preceding therapy showed follicle-stimulating hormone (FSH) levels above 15 mIU/ml, estradiol less than 45 pg/ml and progesterone less than 800 pg/ml. During therapy, there was an improvement in menopausal symptoms, a decrease in luteinizing hormone (LH) and FSH levels, an increase in estradiol levels and the transdermal patches were well tolerated. At the end of therapy, 19 women continued to have regular ovulatory cycles with progesterone levels similar to those in luteal phase. FSH and LH concentrations were significantly lower than before therapy. This study shows that hormone replacement therapy not only improves menopausal symptoms but may also restore the hypothalamic-pituitary-ovarian function.
对32名年龄在42 - 47岁、月经周期不规则且无排卵、有更年期症状的围绝经期女性，评估了经皮雌二醇贴片（0.05毫克/天，共21天）和口服孕激素（10毫克/天，共10天）进行6个月激素替代疗法对下丘脑 - 垂体 - 卵巢功能的影响。治疗前周期的第8天和第24天评估的激素水平显示，促卵泡生成素（FSH）水平高于15 mIU/ml，雌二醇低于45 pg/ml，孕酮低于800 pg/ml。治疗期间，更年期症状有所改善，促黄体生成素（LH）和FSH水平降低，雌二醇水平升高，且经皮贴片耐受性良好。治疗结束时，19名女性继续有规律的排卵周期，孕酮水平与黄体期相似。FSH和LH浓度显著低于治疗前。本研究表明，激素替代疗法不仅能改善更年期症状，还可能恢复下丘脑 - 垂体 - 卵巢功能。
