红细胞硫嘌呤甲基转移酶活性的个体内变异性。
Intraindividual variability in red blood cell thiopurine methyltransferase activity.
作者信息
Giverhaug T, Klemetsdal B, Lysaa R, Aarbakke J
机构信息
Department of Pharmacology, University of Tromsø, Norway.
出版信息
Eur J Clin Pharmacol. 1996;50(3):217-20. doi: 10.1007/s002280050095.
OBJECTIVE
Long-term (13 weeks) and circadian (24 hours) intraindividual variability in red blood cell (RBC) thiopurine methyltransferase (TPMT) activity in healthy subjects was studied.
METHODS
RBC TPMT activity was measured radiochemically.
RESULTS
The variability in RBC TPMT activity was low and was only slightly higher than the imprecision of he TPMT assay. Mean long-term intraindividual variability in RBC TPMT activity was 6.5% (CV) (n = 46). Mean intraindividual circadian variability in RBC TPMT activity was 6.4% (CV) (n = 18).
CONCLUSIONS
In contrast to what has been observed in children with acute lymphoblastic leukaemia, the intraindividual variability in RBC TPMT activity in healthy subjects was low. The reported changes in baseline RBC TPMT activity in patients are probably therefore due to drugs, disease, assay variation or other, unidentified factors.
目的
研究健康受试者红细胞硫嘌呤甲基转移酶（TPMT）活性的长期（13周）和昼夜（24小时）个体内变异性。
方法
采用放射化学法测定红细胞TPMT活性。
结果
红细胞TPMT活性的变异性较低，仅略高于TPMT检测的不精密度。红细胞TPMT活性的平均长期个体内变异性为6.5%（CV）（n = 46）。红细胞TPMT活性的平均个体内昼夜变异性为6.4%（CV）（n = 18）。
结论
与急性淋巴细胞白血病患儿中观察到的情况相反，健康受试者红细胞TPMT活性的个体内变异性较低。因此，患者中报道的基线红细胞TPMT活性变化可能是由于药物、疾病、检测变异或其他未确定的因素。
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