Czarnecki D, Staples M, Mar A, Giles G, Meehan C
Heidelberg Repatriation Hospital, Australia.
Int J Dermatol. 1996 Jun;35(6):410-2. doi: 10.1111/j.1365-4362.1996.tb03022.x.
In retrospective studies of non-melanoma skin cancers, the recurrence rates were relatively high. This study had as its aim to determine the recurrence rate of nonmelanoma skin cancer (NMSC) and prospectively, risk factors for recurrence in southern Australia.
This is a prospective study of outpatients with histologically confirmed NMSC. All patients seen by a dermatologist between November 1988 and November 1989 were entered into the study and followed for at least 3 years. Any recurrent NMSCS were removed and recorded.
Four hundred and eighty-one patients were entered and 420 followed for at least 3 years. A recurrent NMSC developed in 8% (adjusted for losses). A multivariate analysis determined that the main risk factor for recurrence within the first 3 years of follow-up was the number of NMSC a patient had when entering into the study. Those with 3 to nine NMSC were five times more likely to develop a recurrence than those with less than three NMSC. Those with 10 or more NMSC were 25 times more likely to develop a recurrence. Age, sex, and types of skin cancers removed were not risk factors within the first 3 years of follow-up.
Patients who have had multiple skin cancers require careful follow-up because of the risk of developing recurrences.
在非黑色素瘤皮肤癌的回顾性研究中，复发率相对较高。本研究旨在确定澳大利亚南部非黑色素瘤皮肤癌（NMSC）的复发率，并前瞻性地研究复发的危险因素。
这是一项对组织学确诊的NMSC门诊患者的前瞻性研究。1988年11月至1989年11月期间皮肤科医生诊治的所有患者均纳入研究，并随访至少3年。任何复发性NMSCs均被切除并记录。
481例患者纳入研究，420例随访至少3年。8%（校正失访后）出现复发性NMSC。多因素分析确定，随访前3年内复发的主要危险因素是患者纳入研究时NMSC的数量。有3至9个NMSC的患者复发的可能性是少于3个NMSC患者的5倍。有10个或更多NMSC的患者复发的可能性是25倍。年龄、性别和切除的皮肤癌类型在随访的前3年内不是危险因素。
患有多种皮肤癌的患者由于有复发风险，需要密切随访。
