Shakhanbeh J, Abo-Galyon Y
Department of Biology, Mu'tah University, Karak, Jordan.
Skin Pharmacol. 1996;9(3):203-10. doi: 10.1159/000211417.
The effects of mild inflammation induced by topical chloroform treatment on plasma extravasation and mast cell response were studied in normal innervated and denervated rat skin. In the absence of inflammation, the reduction in plasma protein extravasation in response to noxious heat was 31.2% in denervated skin compared to the innervated skin. In the presence of inflammation, the reduction in this response was 52.5% in denervated skin compared to the innervated skin. During inflammation, mast cells became abundant, highly degranulated and migrated to the lower dermal tissue forming large aggregations. The ultrastructural observations showed a close anatomical relationship between mast cells and vesicle-containing nerve profiles. These results indicate that repeated topical chloroform treatment of the rat skin induces neurogenic vascular inflammation accompanied by an increase in mast cell response.
在正常有神经支配和去神经支配的大鼠皮肤上，研究了局部氯仿处理诱导的轻度炎症对血浆外渗和肥大细胞反应的影响。在无炎症情况下，与有神经支配的皮肤相比，去神经支配的皮肤对有害热刺激的血浆蛋白外渗减少了31.2%。在有炎症情况下，与有神经支配的皮肤相比，去神经支配的皮肤这种反应的减少为52.5%。在炎症期间，肥大细胞变得丰富、高度脱颗粒并迁移至真皮下部组织形成大的聚集物。超微结构观察显示肥大细胞与含囊泡的神经纤维之间存在密切的解剖学关系。这些结果表明，对大鼠皮肤反复进行局部氯仿处理会诱导神经源性血管炎症，并伴有肥大细胞反应增加。
