Palm S, Mignat C, Kuhn K, Umbreit H, Barth J, Stüber F, Maier C
Clinic of Anaesthesiology and Surgical Intensive Care, Christian-Albrechts-University, Kiel, Germany.
Methods Find Exp Clin Pharmacol. 1996 Apr;18(3):159-65.
Opioids have been reported in the literature to have immunosuppressive properties. Thus, we investigated the influence of morphine, morphine-3-glucuronide and morphine-6-glucuronide in vitro on phytohemagglutinin-stimulated proliferation of peripheral mononuclear cells from healthy humans. Furthermore, the effects of a 1-week treatment with morphine in a range of 30-240 mg/day on proliferation of lymphocytes from patients with chronic pain syndromes were evaluated. In addition, human peripheral mononuclear cell membranes were tested for specific opioid radioligand binding. The results show that i) morphine and its main metabolites do not influence mitogen-induced T-cell proliferation, ii) treatment of patients with sustained release morphine for 1 week did not impair the lymphocyte proliferative response, and iii) no specific binding of mu-, delta- and kappa-radioligands could be demonstrated to membranes of peripheral lymphocytes obtained from healthy humans. These results do not indicate an impairment of phytohemagglutinin-induced T-cell proliferation during pain treatment with sustained release morphine.
文献报道阿片类药物具有免疫抑制特性。因此，我们在体外研究了吗啡、吗啡 -3 - 葡萄糖醛酸苷和吗啡 -6 - 葡萄糖醛酸苷对来自健康人的外周单个核细胞经植物血凝素刺激后的增殖的影响。此外，还评估了每天30 - 240毫克剂量的吗啡对慢性疼痛综合征患者进行为期1周治疗后对淋巴细胞增殖的影响。另外，检测了人外周单个核细胞膜上特异性阿片类放射性配体的结合情况。结果表明：i）吗啡及其主要代谢产物不影响有丝分裂原诱导的T细胞增殖；ii）对患者进行1周的缓释吗啡治疗并未损害淋巴细胞增殖反应；iii）在从健康人获取的外周淋巴细胞的细胞膜上未检测到μ、δ和κ放射性配体的特异性结合。这些结果表明，在用缓释吗啡进行疼痛治疗期间，植物血凝素诱导的T细胞增殖未受到损害。
