组胺-大鼠丙种球蛋白偶联物对大鼠肥大细胞脱颗粒和组胺释放的抑制作用。
Inhibition of rat mast cell degranulation and histamine release by histamine-rat gammaglobulin conjugate.
作者信息
Ishikawa T, Shimada T, Kessoku N, Kiyoi M
出版信息
Int Arch Allergy Appl Immunol. 1979;59(4):403-7. doi: 10.1159/000232287.
PMID:87381
Abstract
Histamin-rat-gamma-globulin conjugate inhibited degranulation and histamine release of rat peritoneal mast cells to a greater extent than the rat globulin or histamine alone. Since mast cells contain histamine receptors, it may be assumed that the histamine bound to the gamma-globulin combines with the rat mast cell histamine receptor and inhibits the degranulation and histamine release by a feedback mechanism.
摘要
组胺-大鼠γ-球蛋白缀合物比单独的大鼠球蛋白或组胺更能抑制大鼠腹膜肥大细胞的脱颗粒和组胺释放。由于肥大细胞含有组胺受体，可以推测与γ-球蛋白结合的组胺与大鼠肥大细胞组胺受体结合，并通过反馈机制抑制脱颗粒和组胺释放。
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