Hardin-Pouzet H, Giraudon P, Belin M F, Didier-Bazes M
INSERM U433, Faculté de Médecine A. Carrel, Lyon, France.
Brain Res Mol Brain Res. 1996 Apr;37(1-2):324-8. doi: 10.1016/0169-328x(95)00327-o.
Glutamate, the major excitatory neurotransmitter, is preferentially catabolized in astrocytes by glutamate dehydrogenase (GDH). Treatment of an astrocytic cell line with hydrocortisone (10(-5) M) resulted in increased expression of GDH mRNA. Transfection of the cells with truncated parts of the GDH promoter showed that genomic responsive elements activated by hydrocortisone are localized in the -557/+1 region of the promoter. This control of GDH expression by glucocorticoids may be involved in their protective effect against glutamate excitotoxicity.
谷氨酸是主要的兴奋性神经递质，在星形胶质细胞中优先由谷氨酸脱氢酶（GDH）进行分解代谢。用氢化可的松（10^(-5) M）处理星形胶质细胞系会导致GDH mRNA表达增加。用GDH启动子的截短部分转染细胞表明，氢化可的松激活的基因组反应元件位于启动子的-557 / +1区域。糖皮质激素对GDH表达的这种调控可能与其对谷氨酸兴奋性毒性的保护作用有关。
