Fornal C A, Metzler C W, Marrosu F, Ribiero-do-Valle L E, Jacobs B L
Program in Neuroscience, Princeton University, NJ 08544, USA.
Brain Res. 1996 Apr 15;716(1-2):123-33. doi: 10.1016/0006-8993(96)00006-6.
A subgroup of approximately 25% of dorsal raphe nucleus serotonergic neurons in cat was strongly activated in association with oral-buccal movements, such as chewing, licking, and grooming. The mean magnitude of increase in neuronal activity for these cells was approximately 100% above the spontaneous waking level. However, some of these cells were activated by as much as 200-300%. The neuronal activation frequently preceded the initiation of the movement and stopped abruptly in association with either pauses in the motor sequence or with its cessation. Most of the neurons in this subgroup were also strongly and preferentially activated by somatosensory stimuli applied to the head, neck, and face. During orientation to a strong or novel stimulus, the activity of these neurons fell silent for periods of 1-5 s. These data and results from our previous studies of medullary raphe neurons are discussed within the context of the general role of serotonin in tonic and central pattern generator-related motor activity.
猫中约25%的中缝背核5-羟色胺能神经元亚群在与口腔-颊部运动（如咀嚼、舔舐和梳理）相关时被强烈激活。这些细胞的神经元活动增加的平均幅度比清醒时的自发水平高出约100%。然而，其中一些细胞的激活程度高达200%-300%。神经元激活常常在运动开始之前出现，并在运动序列暂停或停止时突然停止。该亚群中的大多数神经元也被施加于头部、颈部和面部的体感刺激强烈且优先激活。在朝向强烈或新异刺激定向时，这些神经元的活动会沉默1-5秒。我们将结合5-羟色胺在紧张性和与中枢模式发生器相关的运动活动中的一般作用，讨论这些数据以及我们之前对延髓中缝神经元研究的结果。
