Vargo J M, Estrick M S, Marshall J F
Department of Psychobiology, University of California, Irvine 92717-4550, USA.
Brain Res. 1996 Apr 15;716(1-2):207-12. doi: 10.1016/0006-8993(96)00027-3.
Functional recovery from cortical injury may result from subcortical compensatory processes. This study examined basal gangliar expression of the immediate early gene c-fos after unilateral medial agranular cortex (AGm) ablation. In the ipsilateral dorsal globus pallidus of rats demonstrating neglect of contralateral stimuli (sacrificed 5 days postinjury), the numbers of amphetamine-induced Fos-positive nuclei were reduced 37% compared to intact hemisphere values. These reductions were no longer apparent in recovered AGm-ablated rats (sacrificed 21 + days postinjury). These findings mirror in timing and direction the changes in Fos seen in dorsolateral striatum after AGm ablation.
皮质损伤后的功能恢复可能源于皮质下的代偿过程。本研究检测了单侧内颗粒层皮质（AGm）切除术后即刻早期基因c-fos在基底神经节的表达。在表现出对侧刺激忽视的大鼠（损伤后5天处死）的同侧背侧苍白球中，苯丙胺诱导的Fos阳性细胞核数量与完整半球相比减少了37%。在恢复的AGm切除大鼠（损伤后21天及以上处死）中，这些减少不再明显。这些发现在时间和方向上与AGm切除后在背外侧纹状体中观察到的Fos变化相呼应。
