Safieh-Garabedian B, Jalakhian R H, Saadé N E, Haddad J J, Jabbur S J, Kanaan S A
Department of Biology, Faculty of Arts and Sciences, American University of Beirut, Lebanon.
Brain Res. 1996 Apr 22;717(1-2):179-83. doi: 10.1016/0006-8993(95)01532-9.
In a new model of peripheral localized inflammation, induced by intraplantar endotoxin (1.25 micrograms) injection in the hind paw of rats and mice, thymulin, a hormone of the thymus gland involved in immunomodulation, reduced inflammatory pain. High doses of thymulin reduced significantly, and in a dose-dependent manner, mechanical hyperalgesia as assessed by the paw pressure test and thermal hyperalgesia as assessed by the hot plate test and tail immersion test.
在一种新的外周局部炎症模型中，通过在大鼠和小鼠后爪足底注射内毒素（1.25微克）诱导炎症，胸腺素（一种参与免疫调节的胸腺激素）可减轻炎症性疼痛。高剂量的胸腺素可显著减轻，且呈剂量依赖性，通过爪压力试验评估的机械性痛觉过敏以及通过热板试验和尾部浸入试验评估的热痛觉过敏。
