颅内脑膜瘤的正电子发射断层扫描（PET）研究：与组织病理学、细胞密度和增殖率的相关性
PET-study of intracranial meningiomas: correlation with histopathology, cellularity and proliferation rate.
作者信息
Lippitz B, Cremerius U, Mayfrank L, Bertalanffy H, Raoofi R, Weis J, Böcking A, Büll U, Gilsbach J M
机构信息
Department of Neurosurgery, Medical Faculty of Technical University Aachen, Federal Republic of Germany.
出版信息
Acta Neurochir Suppl. 1996;65:108-11. doi: 10.1007/978-3-7091-9450-8_30.
The glucose metabolism of 62 meningiomas was measured by fluorine -18-2-fluorodeoxyglucose (FDG) PET and correlated with proliferation rate (Ki-67 index) and tumor cellularity. The mean metabolic rate (MRGlu) for meningiomas was 0.26 +/- 0.13 mikromol/g/min (range 0.08-0.62 mikromol/g/min). The relative tumor FDG-uptake (Q-MRGlu) (tumor/contralateral cortex) of all meningiomas was calculated with 0.73 +/- 0.37 (0.24-1.79). Differences of Q-MRGlu were significant between the groups with high vs. low cellularity (p < 0.01), increased vs. normal proliferation rate (p < 0.025) and low (WHO grade I) vs. higher (WHO grades II, III) graded tumors. In recurrent meningiomas (14 tumors) the glucose metabolism was not increased. The data show that 18 FDG-PET is suitable to serve as non-invasive predictor of tumor growth characteristics in meningiomas.
通过氟-18-2-氟脱氧葡萄糖（FDG）PET测量62例脑膜瘤的葡萄糖代谢，并将其与增殖率（Ki-67指数）和肿瘤细胞密度相关联。脑膜瘤的平均代谢率（MRGlu）为0.26±0.13微摩尔/克/分钟（范围0.08 - 0.62微摩尔/克/分钟）。所有脑膜瘤的相对肿瘤FDG摄取（Q-MRGlu）（肿瘤/对侧皮质）经计算为0.73±0.37（0.24 - 1.79）。高细胞密度组与低细胞密度组（p < 0.01）、增殖率增加组与正常增殖率组（p < 0.025）以及低分级（WHO I级）与高分级（WHO II、III级）肿瘤组之间的Q-MRGlu差异具有统计学意义。在复发性脑膜瘤（14例肿瘤）中，葡萄糖代谢未增加。数据表明，18 FDG-PET适合作为脑膜瘤肿瘤生长特征的非侵入性预测指标。
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