Hohage H, Brückner D, Arlt M, Buchholz B, Zidek W, Spieker C
Medical Department D, Westfälische Wilhelms-Universität, Münster, Germany.
Clin Nephrol. 1996 May;45(5):342-4.
Cyclosporine A (CsA) seems to exert direct effects on blood pressure and diurnal blood pressure alterations. After kidney transplant about 60% of the recipients are suffering from such alterations. In the present study, blood pressure profiles of 15 FK506-treated kidney transplant patients were compared to recipients with CsA immunosuppression. Both groups showed no statistical differences in number, kidney function, age, body weight, sex distribution and time after transplantation. Mean arterial blood pressure in FK506-treated patients at daytime was 105 +/- 2.5 mmHg, at night 109 +/- 3.0 mmHg. Systolic blood pressure difference was 2.3 mmHg, diastolic day/night blood pressure difference 0.6 mmHg, and the difference of the heart frequency 6.8 beats/min. Cyclosporin A-treated patients showed a mean arterial blood pressure during the day of 107 + 2.6 mmHg, at night-time a mean arterial blood pressure of 107 + 3.4 mmHg was measured. The diurnal blood pressure alterations of systolic blood pressure were 0.9 mmHg, diastolic blood pressure difference 3.5 mmHg respectively, the heart frequency showed a difference of 4.4 beats/min. Both, FK506-treated patients and patients with CsA immunosuppression exhibit reduced diurnal blood pressure alterations. Furthermore, mean arterial pressure in both, FK506 and CsA-treated patients was elevated and showed no statistical differences between the groups. In FK506-treated patients, however, antihypertensive therapy was less intensive. Concerning arterial blood pressure and diurnal blood pressure alterations, FK506 offers no advantages as compared to cyclosporine A. The reduced usage of antihypertensive drugs, however, may give evidence for lower hypertensive properties of FK506 as compared to CsA.
环孢素A（CsA）似乎对血压及血压的昼夜变化有直接影响。肾移植后约60%的受者会出现此类变化。在本研究中，将15例接受FK506治疗的肾移植患者的血压情况与接受CsA免疫抑制治疗的受者进行了比较。两组在数量、肾功能、年龄、体重、性别分布及移植后时间方面均无统计学差异。接受FK506治疗的患者白天平均动脉血压为105±2.5 mmHg，夜间为109±3.0 mmHg。收缩压差值为2.3 mmHg，舒张压昼夜差值为0.6 mmHg，心率差值为6.8次/分钟。接受环孢素A治疗的患者白天平均动脉血压为107 + 2.6 mmHg，夜间平均动脉血压为107 + 3.4 mmHg。收缩压的昼夜血压变化分别为0.9 mmHg，舒张压差值为3.5 mmHg，心率差值为4.4次/分钟。接受FK506治疗的患者和接受CsA免疫抑制治疗的患者昼夜血压变化均减小。此外，接受FK506和CsA治疗的患者平均动脉压均升高，且两组间无统计学差异。然而，接受FK506治疗的患者抗高血压治疗强度较低。关于动脉血压及血压的昼夜变化，与环孢素A相比，FK506并无优势。然而，抗高血压药物使用量的减少可能表明与CsA相比，FK506的高血压特性较低。
