Hillan K J, Logan M C, Ferrier R K, Bird G L, Bennett G L, McKay I C, MacSween R N
University Department of Pathology, Western Infirmary, Glasgow.
J Hepatol. 1996 Apr;24(4):385-90. doi: 10.1016/s0168-8278(96)80157-7.
BACKGROUND/METHODS: Hepatocyte growth factor is thought to be important in stimulating growth of the liver following injury. In this study we have measured serum levels of hepatocyte growth factor together with hepatocyte proliferation in liver biopsies, by detection of the Ki-67 antigen, in 23 patients with alcoholic hepatitis.
Serum hepatocyte growth factor was elevated in all patients (median 0.9 ng/ml; range 0.6-7.7 ng/ml; normal < 0.5 ng/ml) and there was a positive correlation between hepatocyte growth factor levels and hepatocyte proliferation in the biopsies.
These results demonstrate that in acute alcoholic hepatitis the liver proliferates in response to injury and suggest that hepatocyte growth factor may be one of the growth factors responsible for this proliferative activity.
背景/方法：肝细胞生长因子被认为在损伤后刺激肝脏生长中起重要作用。在本研究中，我们通过检测Ki-67抗原，测量了23例酒精性肝炎患者肝活检中的肝细胞生长因子血清水平以及肝细胞增殖情况。
所有患者的血清肝细胞生长因子均升高（中位数0.9 ng/ml；范围0.6 - 7.7 ng/ml；正常<0.5 ng/ml），且活检中肝细胞生长因子水平与肝细胞增殖之间存在正相关。
这些结果表明，在急性酒精性肝炎中，肝脏会因损伤而增殖，并提示肝细胞生长因子可能是负责这种增殖活性的生长因子之一。
