Levering S C, Oostelbos M C, Toll P J, Loonen A J
Groot Ziekengasthuis, Department of Clinical Pharmacology, 's-Hertogenbosch, The Netherlands.
Ther Drug Monit. 1996 Jun;18(3):304-5. doi: 10.1097/00007691-199606000-00015.
In this study the effect of the use of lithium heparin containers on the plasma levels of amitriptyline, clomipramine, and their metabolites was investigated. Twenty-five patients (10 men and 15 women, mean age 51.8 +/- 14.9 years) taking either amitriptyline or clomipramine in a daily dosage varying from 50 to 250 mg entered the study after giving informed consent. From each patient, blood samples were taken in a sodium edetate container and in a lithium heparin container in random order. Parent compound levels are equal in sodium edetate and lithium heparin containers. Metabolite levels are 5.6% lower in lithium heparin containers. This difference is not considered clinically relevant.
在本研究中，调查了使用肝素锂容器对阿米替林、氯米帕明及其代谢产物血浆水平的影响。25名患者（10名男性和15名女性，平均年龄51.8±14.9岁），每日服用50至250毫克的阿米替林或氯米帕明，在获得知情同意后进入研究。从每位患者身上，随机顺序采集置于乙二胺四乙酸钠容器和肝素锂容器中的血样。在乙二胺四乙酸钠容器和肝素锂容器中，母体化合物水平相等。肝素锂容器中的代谢产物水平低5.6%。这种差异在临床上不被认为具有相关性。
