Can receptor editing play an important role in normal B-cell development?

B-cells bearing in-frame light chain rearrangements often continue to rearrangement light chain genes, in apparent contradiction to the rules of allelic exclusion. The potential role of B-cell receptor self-reactivity in this process is discussed in the context of the possible efficiency of rescue of the autoreactive cells and the observed high frequency of peripheral B-cells that rearrange only a single light chain locus.