Licinio J, Wong M L, Gold P W
Clinical Neuroendocrinology Branch, National Institute of Mental Health, Bethesda, MD 20892, USA.
Psychiatry Res. 1996 Apr 16;62(1):75-83. doi: 10.1016/0165-1781(96)02991-5.
Studies examining the function of the hypothalamic-pituitary-adrenal (HPA) axis in anorexia nervosa are reviewed. A principal finding is that of hypercortisolism, associated with increased central corticotropin-releasing hormone levels and normal circulating levels of adrenocorticotropic hormone. Similarities between neuroendocrine findings in anorexia nervosa and in affective disorder are reviewed. The contribution of circadian rhythm disturbances and malnutrition to observed HPA axis abnormalities in anorexia nervosa is also considered. Directions for future research are discussed.
本文综述了关于下丘脑 - 垂体 - 肾上腺（HPA）轴在神经性厌食症中功能的研究。一个主要发现是高皮质醇血症，这与中枢促肾上腺皮质激素释放激素水平升高以及促肾上腺皮质激素的正常循环水平相关。文中还综述了神经性厌食症和情感障碍中神经内分泌学发现的相似之处。昼夜节律紊乱和营养不良对神经性厌食症中观察到的HPA轴异常的影响也在考虑范围内。本文讨论了未来研究的方向。
