Mayer G, Hörl W H
Am J Nephrol. 1996;16(4):263-7. doi: 10.1159/000169007.
Partial correction of renal anemia by the use of recombinant human erythropoietin is associated with various effects on cardiovascular performance parameters. A decrease in cardiac output as well as an increase in systemic peripheral resistance have been noted and the pathogenetic basis of these changes will be discussed. Furthermore this article will focus on the potential cardiovascular consequences of prolonged correction of anemia in patients with renal failure. The literature on the clinical implications, such as left ventricular hypertrophy, peripheral arterial occlusive disease and finally patient care costs, will be discussed.
使用重组人促红细胞生成素对肾性贫血进行部分纠正与对心血管性能参数的多种影响相关。已观察到心输出量降低以及全身外周阻力增加，本文将讨论这些变化的发病机制基础。此外，本文将重点关注肾衰竭患者长期纠正贫血可能产生的心血管后果。还将讨论有关临床影响的文献，如左心室肥厚、外周动脉闭塞性疾病以及最终的患者护理成本。
