Rudwaleit M, Schwarz A, Trautmann C, Offermann G, Distler A
Department of Nephrology, Benjamin Franklin Clinic, Free University, Berlin, Germany.
Am J Nephrol. 1996;16(4):344-8. doi: 10.1159/000169021.
The pathogenesis of calciphylaxis, a potentially life-threatening condition, is not well understood. Several factors such as end-stage renal disease (azotemia), hyperparathyroidism, hyperphosphatemia, hypercalcemia, a high calcium-phosphate product, and the use of steroids and cytotoxic drugs after kidney transplantation are believed to interact in calciphylaxis. Recently, hypercoagulability due to functional protein C deficiency has been suggested to play a pathogenic role in this condition. Here, we present a renal transplant patient, with secondary hyperparathyroidism and on long-term oral anticoagulant therapy, who developed calciphylaxis with severe skin necrosis of her legs. The patient's condition improved dramatically after total parathyroidectomy. Hypercoagulability, therefore, does not appear to have played a significant role in this case of calciphylaxis.
钙过敏是一种可能危及生命的疾病，其发病机制尚未完全明确。据信，诸如终末期肾病（氮质血症）、甲状旁腺功能亢进、高磷血症、高钙血症、高钙磷乘积以及肾移植后使用类固醇和细胞毒性药物等多种因素在钙过敏中相互作用。最近，有研究表明功能性蛋白C缺乏导致的高凝状态在这种疾病中起致病作用。在此，我们报告一名患有继发性甲状旁腺功能亢进且长期接受口服抗凝治疗的肾移植患者，该患者出现了钙过敏并伴有腿部严重皮肤坏死。在进行甲状旁腺全切术后，患者的病情显著改善。因此，在该例钙过敏病例中，高凝状态似乎并未发挥重要作用。
