胃分泌中的肥大细胞组胺——对豚鼠胃分离部分的研究

Mast cell histamine in gastric secretion--a study on the isolated portion of a guinea pig stomach.

作者信息

Stanovnik L, Logonder-Mlinsek M

机构信息

Department of Pharmacology, Medical Faculty, University of Ljubljana, Slovenia.

出版信息

Pflugers Arch. 1996;431(6 Suppl 2):R219-20. doi: 10.1007/BF02346347.

DOI:10.1007/BF02346347

PMID:8739343

Abstract

The effects of an H3-agonist, R-alpha-methylhistamine (0.1 and 1 microM), on gastric acid secretion and on mast cell histamine release was studied on the isolated portion of guinea pig stomach. Secretion, induced by calcium ionophore, A23187 (1 microM), and by vagal stimulation was determined by continuous pH measurement, mast cell degranulation was examined histologically. Secretory effects were not significantly changed by H3-agonist. Mast cell degranulation, elicited by vagal stimulation, was not influenced by R-alpha-methylhistamine, but the degranulating effect of A23187 was clearly augmented by the H3-agonist. The results support the view that H3-receptors could influence the release of mast cell histamine in the guinea pig stomach.

摘要

在豚鼠胃的离体部分研究了H3激动剂R-α-甲基组胺（0.1和1微摩尔）对胃酸分泌和肥大细胞组胺释放的影响。通过连续测量pH值来测定由钙离子载体A23187（1微摩尔）和迷走神经刺激诱导的分泌，通过组织学检查肥大细胞脱颗粒情况。H3激动剂对分泌作用没有显著改变。迷走神经刺激引起的肥大细胞脱颗粒不受R-α-甲基组胺影响，但H3激动剂明显增强了A23187的脱颗粒作用。这些结果支持了H3受体可能影响豚鼠胃中肥大细胞组胺释放的观点。