Wisniewski H G, Naime D, Hua J C, Vilcek J, Cronstein B N
Department of Microbiology, Kaplan Cancer Center, New York, USA.
Pflugers Arch. 1996;431(6 Suppl 2):R225-6. doi: 10.1007/BF02346350.
TSG-6 is an arthritis-associated hyaluronan binding protein whose production in synovial cells, chondrocytes, fibroblasts and mononuclear cells is stimulated by TNF-alpha and IL-1. The purpose of this study was to gain insights into the role of TSG-6 and its functional interactions with hyaluronan in inflammation. In the murine air pouch model of carrageenan/IL-1-induced inflammation TSG-6 showed a dramatic inhibitory effect on the cellular infiltration of the inflammatory site by neutrophilic PMN, while hyaluronan enhanced cellular infiltration. There was no indication of a neutralizing or cooperative effect when TSG-6 and hyaluronan were injected together. The potent antiinflammatory effect of TSG-6 along with its induction by proinflammatory cytokines suggests that TSG-6 is part of a negative feedback loop in the control of the inflammatory response.
TSG-6是一种与关节炎相关的透明质酸结合蛋白，肿瘤坏死因子-α（TNF-α）和白细胞介素-1（IL-1）可刺激滑膜细胞、软骨细胞、成纤维细胞和单核细胞产生该蛋白。本研究的目的是深入了解TSG-6的作用及其在炎症中与透明质酸的功能相互作用。在角叉菜胶/IL-1诱导的炎症小鼠气袋模型中，TSG-6对嗜中性多形核白细胞（PMN）向炎症部位的细胞浸润具有显著的抑制作用，而透明质酸则增强了细胞浸润。当TSG-6和透明质酸一起注射时，没有中和或协同作用的迹象。TSG-6的强效抗炎作用及其由促炎细胞因子诱导表明，TSG-6是炎症反应控制中负反馈回路的一部分。
