Katsumi O, Wajima R, Mehta M C, Itabashi R, Arai M, Paranhos F R, Hirose T
Schepens Eye Research Institute, Harvard Medical School, Boston, Massachusetts, USA.
Acta Ophthalmol Scand. 1996 Apr;74(2):171-7. doi: 10.1111/j.1600-0420.1996.tb00065.x.
We compared the pattern reversal visual evoked response (PVER) amplitude-check size functions from 25 eyes (25 normal subjects; visual acuities > or = 20/20) with those from 32 eyes (22 patients; visual acuities 20/15 to 20/50; mean, 20/25.5) with mild optic nerve disease to determine if spatial tuning loss of the PVER occurs in the presence of optic nerve dysfunction. The steady-state PVER was recorded with five check sizes (range, 160 to 10 minutes of arc). To analyze the PVER amplitude-check size function, we calculated the difference between the maximum and minimum PVER amplitudes and then calculated the area of spatial tuning (the area under the function). Values were significantly smaller in patients than in normal subjects (1.81 +/- 1.27 microV versus 5.73 +/- 3.27 microV; F = 41.24, p = 0.0001; 3.87 +/- 2.70 area units versus 12.57 +/- 7.60 area units; F = 38.62, p = 0.0001). There was no shift in the distribution of peak check sizes. Results suggest that a spatial tuning loss occurs in optic nerve disease. The shape of the function, including the area of spatial tuning, appears to be a sensitive indicator of early or mild optic nerve dysfunction.
我们比较了25只眼（25名正常受试者；视力≥20/20）的图形翻转视觉诱发电位（PVER）振幅-视标大小函数与32只眼（22例患者；视力20/15至20/50；平均为20/25.5）患有轻度视神经疾病者的该函数，以确定在存在视神经功能障碍的情况下PVER的空间调谐损失是否会发生。使用五种视标大小（范围为160至10分视角）记录稳态PVER。为了分析PVER振幅-视标大小函数，我们计算了最大和最小PVER振幅之间的差异，然后计算了空间调谐面积（函数下方的面积）。患者的值显著小于正常受试者（1.81±1.27μV对5.73±3.27μV；F = 41.24，p = 0.0001；3.87±2.70面积单位对12.57±7.60面积单位；F = 38.62，p = 0.0001）。峰值视标大小的分布没有偏移。结果表明视神经疾病中会发生空间调谐损失。该函数的形状，包括空间调谐面积，似乎是早期或轻度视神经功能障碍的敏感指标。
