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手部骨骼的软骨肉瘤

Chondrosarcoma of the bones of the hand.

作者信息

Roberts P H, Price C H

出版信息

J Bone Joint Surg Br. 1977 May;59(2):213-21. doi: 10.1302/0301-620X.59B2.873982.

Abstract

Nineteen chondrosarcomas are reported arising in proximal phalanges or metacarpal bones of the hand mainly in elderly patients, predominantly women. The usual clinical presentation was of a progressively painful large tumour, often arising in a dormant lesion near the metacarpo-phalangeal joint. Radiologically most showed some bone expansion with a poorly defined area of destruction and a considerable soft-tissue swelling. Histologically, malignancy was usually obvious, but confusion might arise from the inclusion of bland areas of chondromatous tissue that probably represented the original lesion. Four tumours, initially curetted and grafted, recurred locally and necessitated amputation of the digit or ray. Amputation was the primary treatment for fourteen other tumours and was curative except in one patient who eventually needed amputation through the forearm for a large second recurrence. One tumour was satisfactorily controlled by excision of the affected phalanx. None of these nineteen tumours is known to have metastasised. Correct treatment implies a carefully considered balance between conservation of function and complete removal of all tumour tissue.

摘要

据报道,19例软骨肉瘤发生于手部近端指骨或掌骨,主要见于老年患者,以女性为主。常见的临床表现为逐渐增大且疼痛的肿块,常起源于掌指关节附近的静止性病变。放射学检查显示,大多数病例有一定程度的骨质膨胀,破坏区域边界不清,并有明显的软组织肿胀。组织学检查显示,恶性肿瘤通常较为明显,但由于存在软骨瘤样组织的良性区域(可能代表原发病变),可能会导致诊断混淆。4例肿瘤最初采用刮除植骨治疗,术后局部复发,需行手指或指骨切除。另外14例肿瘤则以截肢作为主要治疗方法,除1例患者因肿瘤复发需行前臂截肢外,其余均治愈。1例肿瘤通过切除患指得到满意控制。这19例肿瘤均未发生转移。正确的治疗方法需要在保留功能和彻底切除所有肿瘤组织之间进行仔细权衡。

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