氟康唑与美西律之间不存在动力学相互作用。
Lack of a kinetic interaction between fluconazole and mexiletine.
作者信息
Ueno K, Yamaguchi R, Tanaka K, Sakaguchi M, Morishima Y, Yamauchi K, Iwai A
机构信息
Department of Pharmacy, National Sengokuso Hospital, Osaka, Japan.
出版信息
Eur J Clin Pharmacol. 1996;50(1-2):129-31. doi: 10.1007/s002280050080.
OBJECTIVE
To investigate the effect of fluconazole on the kinetics of mexiletine.
METHODS
Six healthy male volunteers participated in a crossover study. On the 1st day, the subjects received 200 mg mexiletine alone. On days 2-7 they received 200 mg fluconazole orally, and on day 8 they received 200 mg mexiletine and 200 mg fluconazole concomitantly. In a third phase two subjects received 400 mg fluconazole daily.
RESULTS
No differences in concentrations were observed between the three phases. The area under the concentration curves (AUC) after administration of mexiletine alone and in combination with fluconazole 200 mg/day were 6.63 and 7.31 micrograms.h.ml-1, respectively.
CONCLUSION
These findings suggest that fluconazole does not inhibit mexiletine metabolism.
目的
研究氟康唑对美西律动力学的影响。
方法
6名健康男性志愿者参与了一项交叉研究。第1天，受试者单独服用200毫克美西律。在第2至7天，他们口服200毫克氟康唑，第8天，他们同时服用200毫克美西律和200毫克氟康唑。在第三阶段，两名受试者每天服用400毫克氟康唑。
结果
三个阶段之间未观察到浓度差异。单独服用美西律以及与每天200毫克氟康唑合用时的浓度曲线下面积（AUC）分别为6.63和7.31微克·小时·毫升⁻¹。
结论
这些发现表明氟康唑不抑制美西律代谢。
Zotero 插件