Kusumoto M, Ueno K, Tanaka K, Takeda K, Mashimo K, Kameda T, Fujimura Y, Shibakawa M
Department of Pharmacy, Maizuru Kyosai Hospital, Kyoto, Japan.
Ann Pharmacother. 1998 Feb;32(2):182-4. doi: 10.1345/aph.17177.
To investigate the effect of omeprazole on the pharmacokinetics of mexiletine.
Nine healthy male Japanese volunteers participated in a crossover study. On day 1, the subjects received mexiletine 200 mg. On days 2-7, they received omeprazole 40 mg, and on day 8 they received mexiletine 200 mg and omeprazole 40 mg concomitantly. Serum concentrations of mexiletine were determined just before drug administration and at 1, 2, 3, 4, 6, 8, 12, and 24 hours on day 1 and day 8.
No differences in mexiletine concentrations were observed between the two phases of the study. The mean AUCs after administration of mexiletine alone and in combination with omeprazole 40 mg/d were 6.26 and 6.20 ng.h/L, respectively.
These findings suggest that omeprazole does not affect mexiletine metabolism.
研究奥美拉唑对美西律药代动力学的影响。
9名健康日本男性志愿者参与了一项交叉研究。第1天，受试者服用200毫克美西律。第2 - 7天，他们服用40毫克奥美拉唑，第8天他们同时服用200毫克美西律和40毫克奥美拉唑。在第1天和第8天给药前以及给药后1、2、3、4、6、8、12和24小时测定血清美西律浓度。
研究的两个阶段之间未观察到美西律浓度的差异。单独服用美西律以及与40毫克/天奥美拉唑联合服用后的平均曲线下面积（AUC）分别为6.26和6.20纳克·小时/升。
这些发现表明奥美拉唑不影响美西律的代谢。
