Graf P
Department of Otorhinolaryngology, Södersjukhuset, Karolinska Institute, Stockholm, Sweden.
Rhinology. 1996 Mar;34(1):9-13.
It has been suggested but never confirmed, that the severity of the rebound swelling and rhinitis medicamentosa are directly proportional to the period during which the drug is used, to the frequency of its use, and to the amount of drug administered. However, no studies have been performed to evaluate the effects of various amounts of the vasoconstrictors on the development of rhinitis medicamentosa. Moreover, no in vivo studies have yet been performed to investigate whether benzalkonium chloride in nasal decongestant solutions affects the development of rhinitis medicamentosa. This study shows that rhinitis medicamentosa is a condition of nasal hyperreactivity, mucosal swelling and tolerance induced, or aggravated, by the overuse of topical vasoconstrictors with or without a preservative.
有人提出但从未得到证实，反跳性肿胀和药物性鼻炎的严重程度与用药时间、用药频率以及给药量直接相关。然而，尚未进行研究来评估不同剂量的血管收缩剂对药物性鼻炎发展的影响。此外，尚未进行体内研究来调查鼻减充血剂溶液中的苯扎氯铵是否会影响药物性鼻炎的发展。本研究表明，药物性鼻炎是一种鼻高反应性、黏膜肿胀以及因过度使用含或不含防腐剂的局部血管收缩剂而诱发或加重的耐受性疾病。
