Louis O, Soykens S, Willnecker J, Van den Winkel P, Osteaux M
Radiology Department, Akademisch Ziekenhuis, Vrije Universiteit Brussel, Belgium.
Bone. 1996 May;18(5):467-72. doi: 10.1016/8756-3282(96)00040-3.
The aim of the study was to evaluate the accuracy of an XCT 960 Stratec peripheral quantitative computed tomography (pQCT) device in assessing bone mineral content of the radius. We scanned 27 left forearm specimens excised from cadavers and focused on cortical bone mineral content (BMCc) at the junction of the middle and distal third and on total bone mineral content (BMCtot) at the distal end of the radius. Cylindrical specimens matched with those two sites were cut using a diamond circular saw, embedded in a polyester resin and subsequently submitted to two reference methods, nondestructive neutron activation analysis and flame atomic absorption spectrometry. Mineral contents measured by pQCT were closely correlated with those assessed by using the two reference methods, with correlation coefficients ranging from 0.862 to 0.960. The standard error of the estimate amounted 7-10% for the BMCc (junction of the middle and distal third), and 17-18% for the BMCtot (distal end). We conclude that pQCT is able to measure either cortical or total mineral content of the radius with a high degree of accuracy.
本研究的目的是评估XCT 960 Stratec外周定量计算机断层扫描（pQCT）设备在评估桡骨骨矿物质含量方面的准确性。我们扫描了从尸体上切除的27个左前臂标本，并重点关注桡骨中、远三分之一交界处的皮质骨矿物质含量（BMCc）以及桡骨远端的总骨矿物质含量（BMCtot）。使用金刚石圆锯切割与这两个部位匹配的圆柱形标本，将其嵌入聚酯树脂中，随后采用两种参考方法，即无损中子活化分析和火焰原子吸收光谱法。通过pQCT测量的矿物质含量与使用两种参考方法评估的结果密切相关，相关系数在0.862至0.960之间。对于BMCc（中、远三分之一交界处），估计的标准误差为7 - 10%，对于BMCtot（远端），标准误差为17 - 18%。我们得出结论，pQCT能够高度准确地测量桡骨的皮质或总矿物质含量。
