Harley S, Walsh N
Department of Pathology, Victoria General Hospital, Halifax, Nova Scotia, Canada.
Am J Dermatopathol. 1996 Apr;18(2):137-41. doi: 10.1097/00000372-199604000-00005.
The frequency with which malignant melanomas arise in association with preexisting melanocytic nevi has been studied extensively. We opted to evaluate new aspects of this association. In particular, we addressed the relative proportions of acquired versus congenital nevi involved and categorized the acquired nevi according to morphological type. Approximately 23% of the melanomas (29 of 124) in this group arose in association with preexisting nevi of which 55% (n = 16) were acquired and 28% (n = 8) were congenital (small). In 17% (n = 5) a distinction could not confidently be made. Of the acquired nevi, the vast majority were of Clark's type. It is clear that a relatively small proportion of melanomas as a whole are associated with preexisting nevi, and this number should be kept in perspective in devising strategies for early detection and prevention. The involvement of Clark's nevi in this regard is known, but to date the role of small congenital nevi has been underrecognized.
恶性黑色素瘤与先前存在的黑素细胞痣相关出现的频率已得到广泛研究。我们选择评估这种关联的新方面。特别是，我们探讨了获得性痣与先天性痣的相对比例，并根据形态学类型对获得性痣进行了分类。该组中约23%（124例中的29例）的黑色素瘤与先前存在的痣相关，其中55%（n = 16）为获得性痣，28%（n = 8）为先天性（小）痣。17%（n = 5）无法明确区分。在获得性痣中，绝大多数是克拉克型。显然，总体而言，相对较小比例的黑色素瘤与先前存在的痣相关，在制定早期检测和预防策略时应正确看待这一数字比例关系。克拉克痣在这方面的情况是已知的，但迄今为止，小先天性痣的作用尚未得到充分认识。
