Williams B T, Barr R J
Department of Dermatology, University of California, Irvine, Orange 92668, USA.
Am J Dermatopathol. 1996 Apr;18(2):156-8. doi: 10.1097/00000372-199604000-00008.
Epidermolytic hyperkeratosis (EH) has been described as a reaction pattern in a variety of solitary skin lesions. We have noted that EH seems to occur more frequently in association with atypical than with typical acquired nevi. To support or refute this observation, the prevalence of EH in 250 cases of atypical compound nevi and in 250 cases of typical compound nevi was determined. EH was identified in 10 cases of atypical compound nevi and in two cases of typical compound nevi, which is a statistically significant difference with p value < 0.02. Since EH occurred in only 4% of atypical nevi examined, it should not be considered a diagnostic criterion. However, the identification of EH in otherwise histologically typical nevi should prompt the pathologist to make sure the lesion has been adequately sampled.
表皮松解性角化过度（EH）已被描述为多种孤立性皮肤病变中的一种反应模式。我们注意到，EH似乎在非典型性后天痣中比在典型性后天痣中更频繁地出现。为了支持或反驳这一观察结果，我们测定了250例非典型复合痣和250例典型复合痣中EH的发生率。在10例非典型复合痣和2例典型复合痣中发现了EH，这是一个具有统计学意义的差异，p值<0.02。由于在所检查的非典型痣中只有4%出现EH，因此不应将其视为诊断标准。然而，在组织学上其他方面典型的痣中发现EH，应促使病理学家确保对病变进行了充分取样。
