Zamboni G, Jones C A, Amici R, Perez E, Parmeggiani P L
Dipartimento di Fisiologia umana e generale, Università di Bologna, Italy.
Exp Brain Res. 1996 Apr;109(1):164-8. doi: 10.1007/BF00228639.
The accumulation of adenosine 3':5'-cyclic monophosphate (cAMP) was measured in the preopticanterior hypothalamic area, the cerebral cortex, and the hippocampus of rats exposed to different ambient temperatures: (1) 23 +/- 0.5 degrees C, for 53 h +/- 20 min (control); (2) -10 +/- 1 degrees C, for 53 h +/- 20 min (exposure to low ambient temperature); (3) -10 degrees C for 48 h and 23 degrees C for the following 5 h +/- 20 min (recovery). The capacity to accumulate cAMP was tested by subjecting animals to acute hypoxia, a stimulus which is known to induce a large increase in brain cAMP concentration. In the control condition, hypoxic stimulation increases cAMP concentration in all the brain regions studied. In contrast, during the exposure to low ambient temperature, whilst both the cerebral cortex and the hippocampus show the same levels of accumulation found in the control condition, cAMP accumulation is reduced in the preoptic-anterior hypothalamic area. However, during the first few hours of the recovery period, the preoptic-anterior hypothalamic area is able to reattain the capacity for cAMP accumulation observed in the control condition.
在暴露于不同环境温度的大鼠的视前区-下丘脑前部、大脑皮层和海马中，测量了3':5'-环磷酸腺苷（cAMP）的积累情况：（1）23±0.5摄氏度，持续53小时±20分钟（对照组）；（2）-10±1摄氏度，持续53小时±20分钟（暴露于低环境温度）；（3）-10摄氏度持续48小时，随后23摄氏度持续5小时±20分钟（恢复）。通过使动物遭受急性缺氧来测试积累cAMP的能力，急性缺氧是一种已知会导致脑cAMP浓度大幅增加的刺激。在对照条件下，缺氧刺激会增加所有研究脑区的cAMP浓度。相反，在暴露于低环境温度期间，虽然大脑皮层和海马中的积累水平与对照条件下相同，但视前区-下丘脑前部的cAMP积累减少。然而，在恢复期的最初几个小时内，视前区-下丘脑前部能够重新获得对照条件下观察到的cAMP积累能力。
