Ohls R K, Christensen R D
Department of Pediatrics, School of Medicine, University of New Mexico, Albuquerque 87131, USA.
Ann Pharmacother. 1996 May;30(5):466-8. doi: 10.1177/106002809603000505.
To measure epoetin alfa concentrations after adding it to a variety of commonly used neonatal intravenous fluids to determine the stability of epoetin alfa over time.
Epoetin alfa was added to the following fluids: sterile water; NaCl 0.9%; dextrose 10% in water; dextrose 10% with albumin at concentrations of 0.01%, 0.05%, and 0.1%; and total parenteral nutrition solution containing either 0.5% or 2.25% amino acids. The fluid was administered through intravenous tubing, a T-connector, and catheter, and samples were collected at 0, 2, 4, 8, and 24 hours.
Epoetin alfa concentrations were compared with the measured original preinfusion concentration and recorded as the percentage recovered.
Concentrations declined significantly in all fluids containing less than 0.05% protein, but remained stable over 24 hours in fluids containing 0.05% or more protein.
We conclude that epoetin alfa should be mixed in intravenous fluids containing at least 0.05% protein.
