Lee S, Allard T R
Kaiser Hospital, Woodland Hills, CA, USA.
Ann Pharmacother. 1996 May;30(5):535-7. doi: 10.1177/106002809603000519.
Lodoxamide may be superior compared with cromolyn sodium for treatment of VKC. It is difficult, however, to conclusively determine the superiority of lodoxamide compared with cromolyn from the three studies reviewed in this article. Optimally, a triple-blind, randomized, placebo-controlled, multicenter trial involving the ophthalmic products cromolyn sodium 4%, lodoxamide 0.1%, and placebo (preferably NaCl 0.9%) with a treatment duration of at least 90 days and a similar sample size for each study group would lend the most credence to the determination of superiority of lodoxamide compared with cromolyn sodium for the treatment of VKC.
对于春季角结膜炎（VKC）的治疗，洛度沙胺可能比色甘酸钠更具优势。然而，从本文回顾的三项研究中很难确凿地判定洛度沙胺相较于色甘酸钠的优越性。理想情况下，一项三盲、随机、安慰剂对照、多中心试验，涉及4%的色甘酸钠眼用制剂、0.1%的洛度沙胺眼用制剂和安慰剂（最好是0.9%的氯化钠），治疗持续时间至少90天，且每个研究组样本量相似，这样对于判定洛度沙胺在治疗VKC方面比色甘酸钠更具优越性最具可信度。
