人异常甲状旁腺在体外分泌甲状旁腺激素。

Secretion of parathyroid hormone by abnormal human parathyroid glands in vitro.

作者信息

Birnbaumer M E, Schneider A B, Palmer D, Hanley D A, Sherwood L M

出版信息

J Clin Endocrinol Metab. 1977 Jul;45(1):105-13. doi: 10.1210/jcem-45-1-105.

Abstract

The secretory response of abnormal parathyroid glands obtained surgically from eleven patients with primary and secondary hyperparathyroidsm was tested in vitro. Short term flask studies were used to measure release of parathyroid hormone (PTH) at high (3.0 mM) and low (0.5 mM) calcium. Of eight adenomas, all but one showed increased release of hormone when exposed to low calcium ("responsive to calcium"), the degree of stimulation at three hours ranging from 15 to 209%. By comparison, two normal human glands were stimulated an average of 180%. Glands from three patients with secondary hyperplasia were also responsive to calcium. Thus, parathyroid glands from patients with primary and secondary hyperparathyroidism were characterized by a spectrum of responsiveness to calcium, and absolute "autonomy" was unusual. Even at high calcium concentrations, hormone release persisted at a low but definite level ("basal secretion"). The total number of functioning parathyroid cells is therefore a principal determinant in the oversecretion of PTH in hyperparathyroidism.

摘要

对从11例原发性和继发性甲状旁腺功能亢进患者手术获取的异常甲状旁腺进行了体外分泌反应测试。采用短期培养瓶研究来测量甲状旁腺激素（PTH）在高钙（3.0 mM）和低钙（0.5 mM）条件下的释放。在8个腺瘤中，除1个外，其余所有腺瘤在暴露于低钙时均显示激素释放增加（“对钙有反应”），3小时时的刺激程度为15%至209%。相比之下，2个正常人体甲状旁腺平均受到180%的刺激。3例继发性增生患者的甲状旁腺对钙也有反应。因此，原发性和继发性甲状旁腺功能亢进患者的甲状旁腺表现出一系列对钙的反应性，绝对的“自主性”并不常见。即使在高钙浓度下，激素释放仍维持在低但确定的水平（“基础分泌”）。因此，在甲状旁腺功能亢进中，有功能的甲状旁腺细胞总数是PTH分泌过多的主要决定因素。