Dluhy R G, Greenfield M, Williams G H
J Clin Endocrinol Metab. 1977 Jul;45(1):141-6. doi: 10.1210/jcem-45-1-141.
To assess the relative importance of the renin-antiotensin system and potassium in the acute regulation of aldosterone secretion in the salt depleted state, normal subjects were infused with an asotonic saline solution containing potassium chloride (KCl) and the responses compared to the infusions of isotonic saline (500 ml/h) and KCl alone (20 mEq K+/h). Subjects were studied recumbent in balance on a 10 mEq sodium/100 mEq potassium diet. The rates of infusing saline and potassium were selected to produce comparable but opposite effects on the levels of plasma aldosterone. As plasma renin activity (PRA) declined and plama potassium increased during the combined saline-KCl infusions, plasma aldosterone levels appeared to be the arithmetic sum of the changes in these parameters. In fact, the calculated changes in aldosterone levels per unit change in PRA or potassium from each infusion alone, correlated well with the observed levels, further supporting an additive relationship. These data support the concept that in the salt depleted state the renin-angiotensin system and potassium are equally important in the acute regulation of plasma levels of aldosterone.
为评估肾素 - 血管紧张素系统和钾在盐缺乏状态下醛固酮分泌急性调节中的相对重要性，对正常受试者输注含有氯化钾（KCl）的等渗盐溶液，并将其反应与输注等渗盐水（500 ml/h）和单独输注KCl（20 mEq K⁺/h）的反应进行比较。受试者采用10 mEq钠/100 mEq钾饮食，以平衡卧位状态进行研究。选择输注盐水和钾的速率，以对血浆醛固酮水平产生可比但相反的影响。在联合输注盐水 - KCl期间，随着血浆肾素活性（PRA）下降和血浆钾升高，血浆醛固酮水平似乎是这些参数变化的算术和。事实上，单独每次输注时，醛固酮水平每单位PRA或钾变化的计算值与观察值相关性良好，进一步支持了相加关系。这些数据支持了这样的概念，即在盐缺乏状态下，肾素 - 血管紧张素系统和钾在血浆醛固酮水平的急性调节中同样重要。
