甲氧氯普胺对人体肌肉交感神经活动的影响。

Effect of metoclopramide on muscle sympathetic nerve activity in humans.

作者信息

Takeuchi Y, Matsukawa T, Sugiyama Y, Iwase S, Mano T

机构信息

Department of Autonomic and Behavioral Neurosciences, Nagoya University, Japan.

出版信息

J Auton Nerv Syst. 1996 Apr 20;58(1-2):115-20. doi: 10.1016/0165-1838(95)00137-9.

DOI:10.1016/0165-1838(95)00137-9

PMID:8740668

Abstract

The aim of this study was to determine the effect of metoclopramide on the sympathetic nervous system. Muscle sympathetic nerve activity was increased in two stages after metoclopramide injection. The initial increase in sympathetic nerve activity may result from the unloading of arterial baroreceptors because there was a negative correlation between mean blood pressure and muscle sympathetic nerve activity. The later increase in muscle sympathetic nerve activity may be attributed to the central activation of the sympathetic nervous system because there was a positive correlation between mean blood pressure and muscle sympathetic nerve activity. These results suggest that metoclopramide activates the sympathetic nervous system by two different mechanisms.

摘要

本研究的目的是确定甲氧氯普胺对交感神经系统的影响。注射甲氧氯普胺后，肌肉交感神经活动分两个阶段增加。交感神经活动的初始增加可能是由于动脉压力感受器的卸载，因为平均血压与肌肉交感神经活动之间存在负相关。肌肉交感神经活动的后期增加可能归因于交感神经系统的中枢激活，因为平均血压与肌肉交感神经活动之间存在正相关。这些结果表明，甲氧氯普胺通过两种不同机制激活交感神经系统。