1-（2-四氢呋喃基）-5-氟尿嘧啶与尿嘧啶联合使用可抑制大鼠由7,12-二甲基苯并[a]蒽诱导的乳腺癌发生和肿瘤生长。
1-(2-Tetrahydrofuryl)-5-fluorouracil in combination with uracil suppresses mammary carcinogenesis and growth of tumors induced with 7,12-dimethylbenz[a]anthracene in rats.
作者信息
Sakamoto S, Kudo H, Suzuki S, Sassa S, Yoshimura S, Nakayama T, Maemura M, Mitamura T
机构信息
Medical Research Institute, Tokyo Medical and Dental University, Japan.
出版信息
Anticancer Drugs. 1996 Feb;7(2):199-203. doi: 10.1097/00001813-199602000-00009.
The effects of 1-(2-tetrahydrofuryl)-5-fluorouracil in combination with uracil (UFT) on mammary carcinogenesis and growth of tumors induced with 7,12-dimethylbenz[a]anthracene (DMBA) were investigated in rats. Daily oral administration of UFT reduced the incidence and number of mammary tumors compared with those of the DMBA control group, resulting in lower activities in DNA synthesizing enzymes, thymidylate synthetase and thymidine kinase, and a reduction of bromodeoxyuridine-immunoreactive (S-phase) cells in mammary tumors of UFT-treated rats.
研究了1-(2-四氢呋喃基)-5-氟尿嘧啶与尿嘧啶联合用药（优福定）对大鼠经7,12-二甲基苯并[a]蒽（DMBA）诱导的乳腺癌发生及肿瘤生长的影响。与DMBA对照组相比，每日口服优福定可降低乳腺肿瘤的发生率和数量，导致DNA合成酶、胸苷酸合成酶和胸苷激酶的活性降低，并且优福定治疗的大鼠乳腺肿瘤中溴脱氧尿苷免疫反应性（S期）细胞减少。
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