凝血酶作用下，人血小板磷脂中花生四烯酸的选择性释放。
Selective release of archidonic acid from the phospholipids of human platelets in response to thrombin.
作者信息
Bills T K, Smith J B, Silver M J
出版信息
J Clin Invest. 1977 Jul;60(1):1-6. doi: 10.1172/JCI108745.
Abstract
Arachidonic acid is unique amongst human platelet fatty acids in that it is the precursor of prostaglandins and thromboxanes. Since a number of these oxygenated products of arachidonic acid have potent effects on platelet function, an understanding of the metabolsim of their precursor is important. Human platelets have a mechanism for incorporating arachidonic acid from plasma into their phospholipids and, in response to thrombin, they reveal mechanisms for hydrolyzing this arachidonic acid from platelet phosphatidylcholine and phosphatidylinositol. This report deals with the specificity of these mechanisms. The present studies show that human platelets contain phospholipase A2 activities that preferentially release arachidonic acid. One of these activities specifically utilizes 1-acyl-2-arachidonyl-phosphatidyl-choline. Another utilizes platelet phosphatidylinositol and/or phosphatidylserine, both of which are highly enriched with arachidonic acid.
摘要
花生四烯酸在人类血小板脂肪酸中独具特色，因为它是前列腺素和血栓素的前体。由于花生四烯酸的许多这些氧化产物对血小板功能有强大影响，所以了解其前体的代谢很重要。人类血小板有一种机制，可将血浆中的花生四烯酸纳入其磷脂中，并且在凝血酶的作用下，它们会展现出从血小板磷脂酰胆碱和磷脂酰肌醇中水解这种花生四烯酸的机制。本报告探讨了这些机制的特异性。目前的研究表明，人类血小板含有优先释放花生四烯酸的磷脂酶A2活性。其中一种活性专门作用于1-酰基-2-花生四烯酰基-磷脂酰胆碱。另一种作用于血小板磷脂酰肌醇和/或磷脂酰丝氨酸，这两者都高度富含花生四烯酸。
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