塞内加尔人群组中的HLA - A、- B、- C、- DR、- DQ分型：HLA抗原分布以及使用序列特异性引物的聚合酶链反应（PCR - SSP）对HLA - DRB1*13和DRB1*11进行亚型分型
HLA-A, -B, -C, -DR, -DQ typing in a population group of Senegal: distribution of HLA antigens and HLA-DRB1*13 and DRB1*11 subtyping by PCR using sequence-specific primers (PCR-SSP).
作者信息
Dieye A, Diaw M L, Rogier C, Trape J F, Sarthou J L
机构信息
Immunology Unit Institut Pasteur de Dakar, Sénégal.
出版信息
Tissue Antigens. 1996 Mar;47(3):194-9. doi: 10.1111/j.1399-0039.1996.tb02540.x.
One-hundred-and sixteen Senegalese Serere were typed for HLA antigens and compared with other ethnic groups in Gambia. We did not find significant differences (Fisher's exact test; P < 0.01) in the HLA antigens distribution between the Serere and Mandinka groups in Senegal and the Serere, Mandinka and Wolof in The Gambia. The most common HLA haplotypes found (P < 0.01; Chi square with Yates' correction) were: A1, B8; A2, B51; A32, B44; A33, B58; A2, Cw2; A2, Cw4; A33, Cw3; A2, DR17; A10, DR10; B35, Cw4; B53, Cw6; B57, Cw3; B65, Cw8; B50, DR15; B52, DR4; Cw2, DR17; DR7, DQ2; DR18, DQ4. The HLA-DRB113 and DRB111 alleles were subtyped by PCR-SSP and the frequencies of these alleles in the studied population given. HLA-DRB1*1304 and DRB1102 were the most common alleles found respectively 15.0 and 18.5%.
对116名塞内加尔瑟雷尔人进行了HLA抗原分型，并与冈比亚的其他种族群体进行了比较。我们发现，塞内加尔的瑟雷尔族和曼丁卡族之间以及冈比亚的瑟雷尔族、曼丁卡族和沃洛夫族之间，HLA抗原分布没有显著差异（费舍尔精确检验；P < 0.01）。发现的最常见HLA单倍型（P < 0.01；经耶茨校正的卡方检验）为：A1，B8；A2，B51；A32，B44；A33，B58；A2，Cw2；A2，Cw4；A33，Cw3；A2，DR17；A10，DR10；B35，Cw4；B53，Cw6；B57，Cw3；B65，Cw8；B50，DR15；B52，DR4；Cw2，DR17；DR7，DQ2；DR18，DQ4。通过PCR-SSP对HLA-DRB113和DRB111等位基因进行了亚型分析，并给出了这些等位基因在研究人群中的频率。HLA-DRB1*1304和DRB1102是最常见的等位基因，分别为15.0%和18.5%。
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