与一例黑素瘤病相关的一种新的凝血缺陷。
A new coagulation defect associated with a case of melanomatosis.
作者信息
Phillips J D, O'Shea M J
出版信息
J Clin Pathol. 1977 Jun;30(6):547-50. doi: 10.1136/jcp.30.6.547.
Abstract
A marked abnormality of the intrinsic coagulation system was observed in a patient with melanomatosis and frank melanuria. With successful treatment of the tumour there was a parallel improvement in the clotting abnormality. This defect was shown to be a deficiency of factor XI together with a previously unrecognised factor. This is distinct from either Fletcher or Fitzgerald factors and appears to act between factors XI and X in the coagulation sequence.
摘要
在一名患有黑素瘤病和明显黑尿症的患者中观察到内源性凝血系统存在显著异常。随着肿瘤的成功治疗，凝血异常也相应得到改善。结果表明，这种缺陷是由于缺乏因子XI以及一种先前未被识别的因子。这与弗莱彻因子或菲茨杰拉德因子均不同，并且似乎在凝血序列中作用于因子XI和因子X之间。
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本文引用的文献
1
The relation of 'Fletcher Factor' to factors XI and XII.“弗莱彻因子”与因子XI和因子XII的关系。
Br J Haematol. 1970 Feb;18(2):161-9. doi: 10.1111/j.1365-2141.1970.tb01431.x.
2
Fletcher factor deficiency: family study and detection.弗莱彻因子缺乏症：家族研究与检测
Blood. 1974 May;43(5):641-4.
3
4
The effect of increased contact activation time on the activated partial thromboplastin time.接触激活时间延长对活化部分凝血活酶时间的影响。
Am J Clin Pathol. 1976 Sep;66(3):479-82. doi: 10.1093/ajcp/66.3.479.
5
A new method for the assay of factor XI in plasma and the preparation and use of a new artificial substrate.一种用于测定血浆中因子 XI 的新方法以及一种新型人工底物的制备与应用。
J Clin Pathol. 1975 Apr;28(4):332-6. doi: 10.1136/jcp.28.4.332.
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