Phillips J D, O'Shea M J
J Clin Pathol. 1977 Jun;30(6):547-50. doi: 10.1136/jcp.30.6.547.
A marked abnormality of the intrinsic coagulation system was observed in a patient with melanomatosis and frank melanuria. With successful treatment of the tumour there was a parallel improvement in the clotting abnormality. This defect was shown to be a deficiency of factor XI together with a previously unrecognised factor. This is distinct from either Fletcher or Fitzgerald factors and appears to act between factors XI and X in the coagulation sequence.
在一名患有黑素瘤病和明显黑尿症的患者中观察到内源性凝血系统存在显著异常。随着肿瘤的成功治疗，凝血异常也相应得到改善。结果表明，这种缺陷是由于缺乏因子XI以及一种先前未被识别的因子。这与弗莱彻因子或菲茨杰拉德因子均不同，并且似乎在凝血序列中作用于因子XI和因子X之间。
