颞叶癫痫患者正电子发射断层扫描显示对侧颞叶代谢减低

Contralateral temporal hypometabolism on positron emission tomography in temporal lobe epilepsy.

作者信息

Nagarajan L, Schaul N, Eidelberg D, Dhawan V, Fraser R, Labar D R

机构信息

Comprehensive Epilepsy Center, New York Hospital-Cornell Medical Center, NY 10021, USA.

出版信息

Acta Neurol Scand. 1996 Feb-Mar;93(2-3):81-4. doi: 10.1111/j.1600-0404.1996.tb00178.x.

DOI:10.1111/j.1600-0404.1996.tb00178.x

PMID:8741122

Abstract

INTRODUCTION

No detailed case studies report lateralised hypometabolism on positron emission tomography (PET) contralateral to the epileptogenic focus in temporal lobe epilepsy (TLE).

MATERIAL AND METHODS

We performed 18F fluorodeoxyglucose (FDG) PET in two intractable TLE patients.

RESULTS

One had right temporal interictal spikes on electroencephalography (EEG) and a right medial temporal lobe lesion on magnetic resonance imaging (MRI). FDG-PET showed decreased uptake in the left temporal lobe. Right temporal ictal onset, with bilateral interictal epileptiform activity, occurred on intracranial EEG. He is seizure free after right temporal lobectomy and ganglioglioma resection. The second had right temporal lobe interictal and ictal EEG activity. MRI demonstrated right anteriomedial temporal increased T2 signal. Neuropsychology revealed bilateral cognitive dysfunction. FDG-PET showed left anterior temporal and lateral frontal hypometabolism. He is seizure free after right temporal lobectomy.

CONCLUSION

These findings suggest that regional uptake asymmetry on FDG-PET may be give misleading lateralising information in TLE.

摘要

引言

尚无详细的病例研究报告颞叶癫痫（TLE）患者正电子发射断层扫描（PET）上与致痫灶对侧的偏侧性代谢减低情况。

材料与方法

我们对两名难治性TLE患者进行了18F氟脱氧葡萄糖（FDG）PET检查。

结果

一名患者脑电图（EEG）显示右侧颞叶发作间期棘波，磁共振成像（MRI）显示右侧颞叶内侧病变。FDG-PET显示左侧颞叶摄取减少。颅内脑电图显示右侧颞叶发作起始，伴有双侧发作间期癫痫样活动。该患者在接受右侧颞叶切除术和神经节胶质瘤切除术后无癫痫发作。第二名患者右侧颞叶有发作间期和发作期EEG活动。MRI显示右侧颞叶前内侧T2信号增强。神经心理学检查显示双侧认知功能障碍。FDG-PET显示左侧颞叶前部和额叶外侧代谢减低。该患者在接受右侧颞叶切除术后无癫痫发作。